Rinza

Drug name: Rinza

Other names used:

• Excedrin®

Active Ingredients: Caffeine, paracetamol(acetaminophen)

Therapeutic actions: Paracetamol renders expressed analgesic, febrifugal and anti-inflammatory action. The mechanism of action is connected with suppression of synthesis prostaglandin, mainly in the center heat regulation in hypothalamus. Vasoconstrictive an effect has, reduces a hypostasis of mucous membranes of the top departments of respiratory ways and paranasal sinus.

Caffeine improves a brain blood-groove; strengthens an analgesic action of paracetamol.

Indications:

• Analgesic-antipyretic in patients with aspirin allergy, hemostatic disturbances, bleeding diatheses, upper GI disease, gouty arthritis
• Arthritis and rheumatic disorders involving musculoskeletal pain (but lacks clinically significant antirheumatic and anti-inflammatory effects)
• Common cold, flu, other viral and bacterial infections with pain and fever
• Unlabeled use: prophylactic for children receiving DPT vaccination to reduce incidence of fever and pain

Contraindications and cautions:
- Contraindicated with allergy to acetaminophen.
- Use cautiously with impaired hepatic function, chronic alcoholism, pregnancy, lactation.

Adverse effects: The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

• CNS: Headache
• CV: Chest pain, dyspnea, myocardial damage when doses of 5-8 g/day are ingested daily for several weeks or when doses of 4 g/day are ingested for 1 year
• GI: Hepatic toxicity and failure, jaundice
• GU: Acute kidney failure, renal tubular necrosis
• Hematologic: Methemoglobinemia--cyanosis; hemolytic anemia--hematuria, anuria; neutropenia, leukopenia, pancytopenia, thrombocytopenia, hypoglycemia
• Hypersensitivity: Rash, fever

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

Interactions:

• Increased toxicity with long-term, excessive ethanol ingestion
• Increased hypoprothrombinemic effect of oral anticoagulants
• Increased risk of hepatotoxicity and possible decreased therapeutic effects with barbiturates, carbamazepine, hydantoins, rifampin, sulfinpyrazone
• Possible delayed or decreased effectiveness with anticholinergics
• Possible reduced absorption of acetaminophen with activated charcoal
• Possible decreased effectiveness of zidovudine

Additional Information: DO NOT SHARE THIS MEDICINE with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.